Chinese
Salt of hydrochloric acid of half Guang amine is right active of H -K -ATPase of
From;    Author:Stand originally
Cell of the wall in be being organized by the stomach will finish hydrochloric acid in gastric juice is secreted, h -K -ATP is enzymatic (H -K -ATPase) , renown proton pump, secrete in hydrochloric acid in gastric juice there is crucial effect in the process. It is mixed through oneself phosphation go phosphation, the fluid outside the cell medium K have a change of luck enters a cell inside, outside going against chroma gradient to go out the H pump inside the cell the cell at the same time, the H /K that finish is electrically neutral have a change of luck of the ion that cross film and hydrochloric acid in gastric juice secrete a function. In the cell of consist in wall of concentrated sex of H -K -ATPase, the active of H -K -ATPase increases, hydrochloric acid in gastric juice secretes ability to also increase accordingly, conversely contrary. At present people often judges secrete acerbity function of the stomach with the PH of gastric juice, but because the acidity of gastric juice is fed Mei Hewei the influence of other secretion, what this index can not reflect ability of acid of gastric oneself secrete completely is strong weak. Accordingly, h -K -ATPase can measure hydrochloric acid in gastric juice more accurately to secrete ability objectively not only, also be all hydrochloric acid in gastric juice at the same time the dot of final action target that secretes adjusting control way. In person cure clinical went up to already developed a lot of medicaments that restrain active of H -K -ATPase, be like abstruse beauty Zun, orchid Suo Zun, use remedial hydrochloric acid in gastric juice to secrete overmuch disease, and active to enhancing H -K -ATPase medicaments research is opposite less. Young pig diarrhoea brought huge loss to aquaculture, and hydrochloric acid in gastric juice secretes inadequacy is the main reason that brings about young pig diarrhoea, how to promote hydrochloric acid in gastric juice effectively to secrete the heat that is people attention.

Half Guang amine (Cysteamine, CS) is to grow curb element (Somatostatin, the exhaust agent of SS) , it is passed destroy SS half Guang ammonia is acerbity the 2 sulfur key on incomplete radical, make SS biology active and immune active are lost, remove thereby SS is right inhibition of excretive of hydrochloric acid in gastric juice, stimulative hydrochloric acid in gastric juice is secreted. Although already had a lot of stories about CS, but the hurried that is centered in CS mostly on pasturage grows on action, and CS secretes modulatory research to have not appear in the newspaper to young pig hydrochloric acid in gastric juice. In person cure clinical on CS secretes modulatory research to be animal model with rat mostly to hydrochloric acid in gastric juice, and be given priority to with integral experiment, and the report that studies outside body is less. Below integral circumstance, nerve of excretive of influence hydrochloric acid in gastric juice is humoral the element is very much and very complex, and the cell below the condition outside body does not suffer inside body the influence of complex core condition, the environment all round the cell also is controlled easily, because this combines the test outside body,can study excretive of hydrochloric acid in gastric juice to adjust better. It is no matter the experiment outside body still is inside body, had not seen CS conveys the report that affects with active to H -K -ATPase. Accordingly, this experiment passes salt of hydrochloric acid of half Guang amine (Cysteaminehydrochloride, CSH, the cell of mucous membrane of young pig stomach that active ingredient is the education outside CS) processing system, discuss CSH to convey the influence with active to H -K -ATPase, observe the change that SS conveys at the same time, with period announce in cell and molecular level development the adjustment that CS secretes a function to young pig hydrochloric acid in gastric juice and its likely action mechanism.
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