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Peptide of casein phosphoric acid (CPP) and research of nutrition of calcic, iro
From;    Author:Stand originally
Current, the biology active peptide with relatively extensive research basically originates bovine cheese albumen, this kind of peptide has immunity, analgesia, promote mineral absorb wait for function of a lot of biology. Among them, research is more is peptide of casein phosphoric acid (CPP) , it is with bovine cheese albumen is raw material, through the hydrolyze with onefold or compound enzymatic albumen, the peptide of natural physiology active that contains acid of ammonia of phosphoric acid silk to form a cluster to what get after hydrolysis child is detached and rarefied again, have combinative calcium and the function that stimulative calcium absorbs, also have effect to raising the biology utilization rate of iron at the same time.

1The origin of CPP and molecular structure

Casein occupies bovine milk total protein 80% the left and right sides, casein of main S1- having α , α S2- casein, β - casein, κ - casein composition. CPP basically is by α S1- casein, α S2- casein, β - casein classics after trypsin hydrolyze, the opposite element amount of generation is not even, and the polypeptide that contains a lot ofSer-P. Theoretic can produce peptide of 8 kinds of phosphoric acid, among them most typical have the following 4 kinds.
β of Sequence 1 [- CN(1-25)] :

Arg1-Glu-Leu-Glu-Glu-Leu-Asn-Val-Pro-Gly-Glu-Ile-Val-Glu-Ser (P) - Leu-Ser (P) 3-Glu2-Ser-Ile-Thr-Arg25.
S1-CN(59-79)] of α of Sequence 2 [:

Gln59-Met-Glu-Ala-Glu-Ser(P)-Ile-Ser(P)3-Glu2-Ile-Val-Pro-Asn-Ser(P)-Val-Glu-Gln-Lys79.
S2-CN(46-70)] of α of Sequence 3 [:

Asn46-Ala-Asn-Glu-Glu-Glu-Tyr-Ser-Ile-Gly-Ser(P)3-Glu2-Ser(P)-Ala-Glu-Val-Ala-Thr-Glu-Glu- Val-Lys70.
S2-CN(1-21)] of α of Sequence 4 [:

Lys1-Asn-Thr-Met-Glu-His-Val-Ser(P)3-Glu2-Ser-Ile-Ile-Ser(P)-Gln-Glu -Thr-Tyr-Lys21.

Its structure characteristic contains common core position is SerP-SerP-SerP-Glu-Glu. Place of this one core is the crucial area of function of CPP play biology, can be united in wedlock with the diatomic ion such as calcic, iron, ammonia of phosphoric acid silk is acerbity at the same time base on contained negative electric charge can prevent CPP to be digested inside alvine path enzymatic degradation.

2CPP and the nutrition of calcic, iron

2.1CPP and calcic nutrition

CPP is the earliest be to serve as hurried to calcium absorbs factor and be discovered. Calcium is the element of the demand in mineral nutrition is the biggest a kind of constant inside animal body, main effect is having in maintaining airframe construction and physiology function, also be the material of main physiology active of cell and blood. Because many establish acerbity salt, cellulose, oxalic acid is contained to wait in feed, they can be generated with Ca2 union not material of dissolve sex precipitation, restrained an animal to be used to calcic absorption thereby. Accordingly, aborning besides seeking good calcic compensatory preparation, the absorption that raises existing calcium also is a very significant step. Main to calcic absorption show is in CPP stimulative animal 3 respects: Small intestine, skeleton and tooth.
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